Three singles bolstered First Impressions. “Juicebox,” the album’s first single, was released earlier than planned due to a leak. The aggressively powerful and harsh song provided a solid base for the album. As their highest charting single, the song was also their first to reach the Billboard Hot 100 . The album’s second single, “Heart in a Cage,” also did fairly well. Lastly, the album’s third single and opening song “You Only Live Once” received an impressive response. Its music video has reached over sixty million views, and the song itself was named in Rolling Stone’s 100 Best Songs of 2006.